Abstract

This review paper aims to critically assess the advancements, challenges, and future prospects of kidney-on-chip (KOC) technology in studying antibiotic-induced kidney injury. Despite significant progress, challenges such as limited throughput and the need for more accurate physiological replication persist. By analyzing current literature and technological developments, this review identifies key issues and outlines future directions for KOC research. Through an exploration of sensor integration, high-throughput screening capabilities, and automation, this review seeks to address these challenges and propel KOC toward more efficient and predictive drug-testing methodologies.